| Primary Identifier | MGI:2384045 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Snrpn |
| Transmission | Germline | Strain of Origin | 129S7/SvEvBrd-Hprt1<b-m2> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A 6 kb region of the gene encompassing exon 2 was replaced with an HPRT-loxP-neo cassette via homologous recombination resulting in deletion of 32 amino acids from the smaller of 2 open reading frames. The larger downstream open reading frame remains intact. RT-PCR analysis of heterozygous mutant animals showed expression of only wild-type transcripts in mice carrying a maternally derived mutation, and in mice carrying a paternally derived mutation the mutant transcript and transcripts of the neo gene are expressed. The deletion does not affect maternal-paternal imprinting of the DNA. |
