|  Help  |  About  |  Contact Us

Allele : Tg(Ins-BCL2L1)2Ksp transgene insertion 2, Kenneth S Polonsky
Primary Identifier  MGI:2384545 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(Ins-BCL2L1)2Ksp
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  0.82 kb of human BCL2L1 cDNA preceded by 12.9 kb of rat insulin promoter and enhancer sequences was used for the transgene. Specific expression of the transgene in beta-cells of the pancreas was confirmed by immunohistochemical analysis. Protein staining was detected in beta-cells of transgenic animals, but not in non-beta-cells, liver, exocrine tissue, small intestine, or lymph nodes. Western blot analysis showed expression of the human protein is at least 10-fold greater that of endogenous protein.
  • mutations:
  • Insertion
  • synonyms:
  • Fd 2 Bcl-xL,
  • Fd 2 Bcl-xL,
  • RIP7-Bcl-xL,
  • RIP7-Bcl-xL
Paste the following link
Quick Links:
SummaryGenomePhenotypeOther
 
Quick Links:
SummaryGenomePhenotypeOther
 
Lists
This Allele isn't in any lists. Upload a list.

1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

9 Publication categories

Trail: Allele




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom