| First Author | Zacarías-Fluck MF | Year | 2021 |
| Journal | Life Sci Alliance | Volume | 4 |
| Issue | 5 | PubMed ID | 33653688 |
| Mgi Jnum | J:303603 | Mgi Id | MGI:6690911 |
| Doi | 10.26508/lsa.201900490 | Citation | Zacarias-Fluck MF, et al. (2021) The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets. Life Sci Alliance 4(5) |
| abstractText | The huge cadre of genes regulated by Myc has obstructed the identification of critical effectors that are essential for Myc-driven tumorigenesis. Here, we describe how only the lack of the receptor Fzd9, previously identified as a Myc transcriptional target, impairs sustained tumor expansion and beta-cell dedifferentiation in a mouse model of Myc-driven insulinoma, allows pancreatic islets to maintain their physiological structure and affects Myc-related global gene expression. Importantly, Wnt signaling inhibition in Fzd9-competent mice largely recapitulates the suppression of proliferation caused by Fzd9 deficiency upon Myc activation. Together, our results indicate that the Wnt signaling receptor Fzd9 is essential for Myc-induced tumorigenesis in pancreatic islets. |
