| First Author | Lebson L | Year | 2010 |
| Journal | J Immunol | Volume | 185 |
| Issue | 12 | Pages | 7161-4 |
| PubMed ID | 21076063 | Mgi Jnum | J:167470 |
| Mgi Id | MGI:4868324 | Doi | 10.4049/jimmunol.1002750 |
| Citation | Lebson L, et al. (2010) Cutting edge: The transcription factor Kruppel-like factor 4 regulates the differentiation of Th17 cells independently of RORgammat. J Immunol 185(12):7161-4 |
| abstractText | Th17 cells play a significant role in inflammatory and autoimmune responses. Although a number of molecular pathways that contribute to the lineage differentiation of T cells have been discovered, the mechanisms by which lineage commitment occurs are not fully understood. Transcription factors play a key role in driving T cells toward specific lineages. We have identified a role for the transcription factor Kruppel-like factor (KLF) 4 in the development of IL-17-producing CD4(+) T cells. KLF4 was required for the production of IL-17, and further, chromatin immunoprecipitation analysis demonstrated binding of KLF4 to the IL-17 promoter, indicating a direct effect on the regulation of IL-17. Further, KLF4-deficient T cells upregulated expression of retinoic acid-related orphan receptor gammat similar to wild-type during the polarization process toward Th17, suggesting that these two transcription factors are regulated independently. |
