| Primary Identifier | MGI:2183945 | Allele Type | Targeted |
| Attribute String | Hypomorph | Gene | Ercc1 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A stop codon was introduced at position 292 to shorten the protein by 7 residues, 2 of which are in the essential domain. Expression and sequence analysis showed message to be transcribed and processed properly in homozygous mutant mice. RT-PCR analysis revealed levels of transcript to be approximately 15% of those in wild-type mice. Further analysis showed that transcription of the antisense gene was unaffected by the targeting event. |
