| First Author | Kant S | Year | 2011 |
| Journal | Genes Dev | Volume | 25 |
| Issue | 19 | Pages | 2069-78 |
| PubMed ID | 21979919 | Mgi Jnum | J:177426 |
| Mgi Id | MGI:5295095 | Doi | 10.1101/gad.17224711 |
| Citation | Kant S, et al. (2011) TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway. Genes Dev 25(19):2069-78 |
| abstractText | The biological response to tumor necrosis factor (TNF) involves activation of MAP kinases. Here we report a mechanism of MAP kinase activation by TNF that is mediated by the Rho GTPase family members Rac/Cdc42. This signaling pathway requires Src-dependent activation of the guanosine nucleotide exchange factor Vav, activation of Rac/Cdc42, and the engagement of the Rac/Cdc42 interaction site (CRIB motif) on mixed-lineage protein kinases (MLKs). We show that this pathway is essential for full MAP kinase activation during the response to TNF. Moreover, this MLK pathway contributes to inflammation in vivo. |
