| First Author | Hu D | Year | 2015 |
| Journal | Immunity | Volume | 42 |
| Issue | 6 | Pages | 1100-15 |
| PubMed ID | 26084025 | Mgi Jnum | J:229110 |
| Mgi Id | MGI:5750818 | Doi | 10.1016/j.immuni.2015.05.015 |
| Citation | Hu D, et al. (2015) Artery Tertiary Lymphoid Organs Control Aorta Immunity and Protect against Atherosclerosis via Vascular Smooth Muscle Cell Lymphotoxin beta Receptors. Immunity 42(6):1100-15 |
| abstractText | Tertiary lymphoid organs (TLOs) emerge during nonresolving peripheral inflammation, but their impact on disease progression remains unknown. We have found in aged Apoe(-/-) mice that artery TLOs (ATLOs) controlled highly territorialized aorta T cell responses. ATLOs promoted T cell recruitment, primed CD4(+) T cells, generated CD4(+), CD8(+), T regulatory (Treg) effector and central memory cells, converted naive CD4(+) T cells into induced Treg cells, and presented antigen by an unusual set of dendritic cells and B cells. Meanwhile, vascular smooth muscle cell lymphotoxin beta receptors (VSMC-LTbetaRs) protected against atherosclerosis by maintaining structure, cellularity, and size of ATLOs though VSMC-LTbetaRs did not affect secondary lymphoid organs: Atherosclerosis was markedly exacerbated in Apoe(-/-)Ltbr(-/-) and to a similar extent in aged Apoe(-/-)Ltbr(fl/fl)Tagln-cre mice. These data support the conclusion that the immune system employs ATLOs to organize aorta T cell homeostasis during aging and that VSMC-LTbetaRs participate in atherosclerosis protection via ATLOs. |
