| First Author | Yau IW | Year | 2013 |
| Journal | J Immunol | Volume | 191 |
| Issue | 3 | Pages | 1082-90 |
| PubMed ID | 23817432 | Mgi Jnum | J:205710 |
| Mgi Id | MGI:5546281 | Doi | 10.4049/jimmunol.1201569 |
| Citation | Yau IW, et al. (2013) Censoring of self-reactive B cells by follicular dendritic cell-displayed self-antigen. J Immunol 191(3):1082-90 |
| abstractText | In the secondary lymphoid organs, intimate contact with follicular dendritic cells (FDCs) is required for B cell retention and Ag-driven selection during the germinal center response. However, selection of self-reactive B cells by Ag on FDCs has not been addressed. To this end, we generated a mouse model to conditionally express a membrane-bound self-antigen on FDCs and to monitor the fate of developing self-reactive B cells. In this article, we show that self-antigen displayed on FDCs mediates effective elimination of self-reactive B cells at the transitional stage. Notwithstanding, some self-reactive B cells persist beyond this checkpoint, showing evidence of Ag experience and intact proximal BCR signaling, but they are short-lived and unable to elicit T cell help. These results implicate FDCs as an important component of peripheral B cell tolerance that prevents the emergence of naive B cells capable of responding to sequestered self-antigens. |
