| First Author | Kilmon MA | Year | 2005 |
| Journal | J Immunol | Volume | 175 |
| Issue | 1 | Pages | 37-41 |
| PubMed ID | 15972629 | Mgi Jnum | J:100598 |
| Mgi Id | MGI:3588919 | Doi | 10.4049/jimmunol.175.1.37 |
| Citation | Kilmon MA, et al. (2005) Low-affinity, Smith antigen-specific B cells are tolerized by dendritic cells and macrophages. J Immunol 175(1):37-41 |
| abstractText | Polyclonal B cell activation promotes immunity without the loss of tolerance. Our data show that during activation of the innate immune system, B cell tolerance to Smith Ag Sm is maintained by dendritic cells (DCs) and macrophages (MPhi). TLR4-activated myeloid DCs and MPhi, but not plasmacytoid or lymphoid DCs, repressed autoreactive B cells through the secretion of soluble mediators, including IL-6. Although IL-6 promotes plasma cell differentiation of B cells acutely stimulated by Ag, we show that it repressed cells that were chronically exposed to self-Ag. This mechanism of tolerance was not limited to Smith Ag-specific B cells as hen egg lysozyme- and p-azophenylarsonate-specific B cells were similarly affected. Our data define a tolerogenic role for MPhi and DCs in regulating autoreactive B cells during activation of the innate immune system. |
