| First Author | Benson RA | Year | 2015 |
| Journal | Elife | Volume | 4 |
| PubMed ID | 26258879 | Mgi Jnum | J:226648 |
| Mgi Id | MGI:5698020 | Doi | 10.7554/eLife.06994 |
| Citation | Benson RA, et al. (2015) Antigen presentation kinetics control T cell/dendritic cell interactions and follicular helper T cell generation in vivo. Elife 4 |
| abstractText | The production of high affinity, class switched antibodies produced by B cells hinges on the effective differentiation of T follicular helper (Tfh) cells. Here we define conditions specifically enhancing Tfh differentiation and providing protection in a model of influenza infection. Tfh responses were associated with prolonged antigen presentation by dendritic cells (DCs), which maintained T cell/DC interactions into stage 3 (>72 hr) of activation. Blocking stage 3 interactions ablated Tfh generation, demonstrating a causal link between T cell-DC behaviour and functional outcomes. The current data therefore explain how duration of antigen presentation affects the dynamics of T cell-DC interactions and consequently determine Tfh cell differentiation in the developing immune response. |
