| Primary Identifier | MGI:2383989 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Fdft1 |
| Transmission | Germline | Strain of Origin | 129S7/SvEvBrd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exons 4 and 5 were replaced with a neomycin selection cassette. Northern blot analysis of total hepatic RNA from heterozygous mice showed transcript levels to be reduced to 40% of normal. Squalene synthase activity was determined to be reduced by 50% in heterozygous mice via an assay of liver and testis homogenates. |
