| First Author | Hamerman JA | Year | 2005 |
| Journal | Nat Immunol | Volume | 6 |
| Issue | 6 | Pages | 579-86 |
| PubMed ID | 15895090 | Mgi Jnum | J:98956 |
| Mgi Id | MGI:3580771 | Doi | 10.1038/ni1204 |
| Citation | Hamerman JA, et al. (2005) Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat Immunol 6(6):579-86 |
| abstractText | DAP12 is a signaling adaptor containing an immunoreceptor tyrosine-based activation motif (ITAM) that pairs with receptors on myeloid cells and natural killer cells. We examine here the responses of mice lacking DAP12 to stimulation through Toll-like receptors (TLRs). Unexpectedly, DAP12-deficient macrophages produced higher concentrations of inflammatory cytokines in response to a variety of pathogenic stimuli. Additionally, macrophages deficient in spleen tyrosine kinase (Syk), which signals downstream of DAP12, showed a phenotype identical to that of DAP12-deficient macrophages. DAP12-deficient mice were more susceptible to endotoxic shock and had enhanced resistance to infection by the intracellular bacterium Listeria monocytogenes. These data suggest that one or more DAP12-pairing receptors negatively regulate signaling through TLRs. |
