| First Author | Lan Q | Year | 2012 |
| Journal | J Mol Cell Biol | Volume | 4 |
| Issue | 6 | Pages | 409-19 |
| PubMed ID | 22773728 | Mgi Jnum | J:325793 |
| Mgi Id | MGI:6872548 | Doi | 10.1093/jmcb/mjs040 |
| Citation | Lan Q, et al. (2012) Polyclonal CD4+Foxp3+ Treg cells induce TGFbeta-dependent tolerogenic dendritic cells that suppress the murine lupus-like syndrome. J Mol Cell Biol 4(6):409-19 |
| abstractText | Interplay between Foxp3(+) regulatory T cells (Treg) and dendritic cells (DCs) maintains immunologic tolerance, but the effects of each cell on the other are not well understood. We report that polyclonal CD4(+)Foxp3(+) Treg cells induced ex vivo with transforming growth factor beta (TGFbeta) (iTreg) suppress a lupus-like chronic graft-versus-host disease by preventing the expansion of immunogenic DCs and inducing protective DCs that generate additional recipient CD4(+)Foxp3(+) cells. The protective effects of the transferred iTreg cells required both interleukin (IL)-10 and TGFbeta, but the tolerogenic effects of the iTreg on DCs, and the immunosuppressive effects of these DCs were exclusively TGFbeta-dependent. The iTreg were unable to tolerize Tgfbr2-deficient DCs. These results support the essential role of DCs in 'infectious tolerance' and emphasize the central role of TGFbeta in protective iTreg/DC interactions in vivo. |
