| First Author | Gewin L | Year | 2012 |
| Journal | J Am Soc Nephrol | Volume | 23 |
| Issue | 12 | Pages | 2001-11 |
| PubMed ID | 23160515 | Mgi Jnum | J:330776 |
| Mgi Id | MGI:6837135 | Doi | 10.1681/ASN.2012020139 |
| Citation | Gewin L, et al. (2012) Deleting the TGF-beta receptor attenuates acute proximal tubule injury. J Am Soc Nephrol 23(12):2001-11 |
| abstractText | TGF-beta is a profibrotic growth factor in CKD, but its role in modulating the kidney's response to AKI is not well understood. The proximal tubule epithelial cell, which is the main cellular target of AKI, expresses high levels of both TGF-beta and its receptors. To determine how TGF-beta signaling in this tubular segment affects the response to AKI, we selectively deleted the TGF-beta type II receptor in the proximal tubules of mice. This deletion attenuated renal impairment and reduced tubular apoptosis in mercuric chloride-induced injury. In vitro, deficiency of the TGF-beta type II receptor protected proximal tubule epithelial cells from hydrogen peroxide-induced apoptosis, which was mediated in part by Smad-dependent signaling. Taken together, these results suggest that TGF-beta signaling in the proximal tubule has a detrimental effect on the response to AKI as a result of its proapoptotic effects. |
