Other
12 Authors
- Hirsh DM,
- Majeska RJ,
- Kim SJ,
- Goldring MB,
- Leong DJ,
- Lu L,
- Sun HB,
- Cobelli NJ,
- Xu L,
- Feng H,
- He Z,
- Liu L
| First Author | Liu L | Year | 2019 |
| Journal | Ann N Y Acad Sci | Volume | 1442 |
| Issue | 1 | Pages | 153-164 |
| PubMed ID | 30891782 | Mgi Jnum | J:290252 |
| Mgi Id | MGI:6442139 | Doi | 10.1111/nyas.14025 |
| Citation | Liu L, et al. (2019) CITED2 mediates the mechanical loading-induced suppression of adipokines in the infrapatellar fat pad. Ann N Y Acad Sci 1442(1):153-164 |
| abstractText | Adipokines secreted from the infrapatellar fat pad (IPFP), such as adipsin and adiponectin, have been implicated in osteoarthritis pathogenesis. CITED2, a mechanosensitive transcriptional regulator with chondroprotective activity, may modulate their expression. Cited2 haploinsufficient mice (Cited2(+/-) ) on a high-fat diet (HFD) exhibited increased body weight and increased IPFP area compared to wild-type (WT) mice on an HFD. While an exercise regimen of moderate treadmill running induced the expression of CITED2, as well as PGC-1alpha, and reduced the expression of adipsin and adiponectin in the IPFP of WT mice on an HFD, Cited2 haploinsufficiency abolished the loading-induced expression of PGC-1alpha and loading-induced suppression of adipsin and adiponectin. Furthermore, knocking down or knocking out CITED2 in adipose stem cells (ASCs)/preadipocytes derived from the IPFP in vitro led to the increased expression of adipsin and adiponectin and reduced PGC-1alpha, and abolished the loading-induced suppression of adipsin and adiponectin and loading-induced expression of PGC-1alpha. Overexpression of PGC-1alpha in these ASC/preadipocytes reversed the effects caused by CITED2 deficiency. The current data suggest that CITED2 is a critical regulator in physiologic loading-induced chondroprotection in the context of an HFD and PGC-1alpha is required for the inhibitory effects of CITED2 on the expression of adipokines such as adipsin and adiponectin in the IPFP. |
