| First Author | Tager AM | Year | 2003 |
| Journal | Nat Immunol | Volume | 4 |
| Issue | 10 | Pages | 982-90 |
| PubMed ID | 12949531 | Mgi Jnum | J:85816 |
| Mgi Id | MGI:2677090 | Doi | 10.1038/ni970 |
| Citation | Tager AM, et al. (2003) Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment. Nat Immunol 4(10):982-90 |
| abstractText | Leukotriene B4 (LTB4) was originally described as a potent lipid myeloid cell chemoattractant, rapidly generated from innate immune cells, that activates leukocytes through the G protein-coupled receptor BLT1. We report here that BLT1 is expressed on effector CD4+ T cells generated in vitro as well as in vivo when effector T cells migrate out of the lymphoid compartment and are recruited into peripheral tissues. BLT1 mediated LTB4-induced T helper type 1 (T(H)1) and T(H)2 cell chemotaxis and firm adhesion to endothelial cells under flow, as well as early CD4+ and CD8+ T cell recruitment into the airway in an asthma model. Our findings show that the LTB4-BLT1 pathway is involved in linking early immune system activation and early effector T cell recruitment. |
