| First Author | Duteil D | Year | 2016 |
| Journal | Cell Rep | Volume | 17 |
| Issue | 4 | Pages | 1008-1021 |
| PubMed ID | 27760309 | Mgi Jnum | J:240758 |
| Mgi Id | MGI:5892183 | Doi | 10.1016/j.celrep.2016.09.053 |
| Citation | Duteil D, et al. (2016) Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue. Cell Rep 17(4):1008-1021 |
| abstractText | Previous work indicated that lysine-specific demethylase 1 (Lsd1) can positively regulate the oxidative and thermogenic capacities of white and beige adipocytes. Here we investigate the role of Lsd1 in brown adipose tissue (BAT) and find that BAT-selective Lsd1 ablation induces a shift from oxidative to glycolytic metabolism. This shift is associated with downregulation of BAT-specific and upregulation of white adipose tissue (WAT)-selective gene expression. This results in the accumulation of di- and triacylglycerides and culminates in a profound whitening of BAT in aged Lsd1-deficient mice. Further studies show that Lsd1 maintains BAT properties via a dual role. It activates BAT-selective gene expression in concert with the transcription factor Nrf1 and represses WAT-selective genes through recruitment of the CoREST complex. In conclusion, our data uncover Lsd1 as a key regulator of gene expression and metabolic function in BAT. |
