| First Author | Sheng HZ | Year | 1997 |
| Journal | Science | Volume | 278 |
| Issue | 5344 | Pages | 1809-12 |
| PubMed ID | 9388186 | Mgi Jnum | J:44644 |
| Mgi Id | MGI:1100668 | Doi | 10.1126/science.278.5344.1809 |
| Citation | Sheng HZ, et al. (1997) Multistep control of pituitary organogenesis. Science 278(5344):1809-12 |
| abstractText | Lhx3 and Lhx4 (Gsh4), two closely related LIM homeobox genes, determine formation of the pituitary gland in mice. Rathke's pouch is formed in two steps-first as a rudiment and later as a definitive pouch. Lhx3 and Lhx4 have redundant control over formation of the definitive pouch. Lhx3 controls a subsequent step of pituitary fate commitment. Thereafter, Lhx3 and Lhx4 together regulate proliferation and differentiation of pituitary-specific cell lineages. Thus, Lhx3 and Lhx4 dictate pituitary organ identity by controlling developmental decisions at multiple stages of organogenesis. |
