| First Author | Etkin A | Year | 2006 |
| Journal | Neuron | Volume | 50 |
| Issue | 1 | Pages | 127-43 |
| PubMed ID | 16600861 | Mgi Jnum | J:110972 |
| Mgi Id | MGI:3652465 | Doi | 10.1016/j.neuron.2006.03.013 |
| Citation | Etkin A, et al. (2006) A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context. Neuron 50(1):127-43 |
| abstractText | Whereas significant insight exists as to how LTP-related changes can contribute to the formation of long-term memory, little is known about the role of hippocampal LTD-like changes in learning and memory storage. We describe a mouse lacking the transcription factor SRF in the adult forebrain. This mouse could not acquire a hippocampus-based immediate memory for a novel context even across a few minute timespan, which led to a profound but selective deficit in explicit spatial memory. These animals were also impaired in the induction of LTD, including LTD triggered by a cholinergic agonist. Moreover, genes regulating two processes essential for LTD-calcium release from intracellular stores and phosphatase activation-were abnormally expressed in knockouts. These findings suggest that for the hippocampus to form associative spatial memories through LTP-like processes, it must first undergo learning of the context per se through exploration and the learning of familiarity, which requires LTD-like processes. |
