| First Author | Lin L | Year | 2004 |
| Journal | Eur J Immunol | Volume | 34 |
| Issue | 5 | Pages | 1483-7 |
| PubMed ID | 15114682 | Mgi Jnum | J:346483 |
| Mgi Id | MGI:7616528 | Doi | 10.1002/eji.200324736 |
| Citation | Lin L, et al. (2004) CpG DNA redirects class-switching towards "Th1-like" Ig isotype production via TLR9 and MyD88. Eur J Immunol 34(5):1483-7 |
| abstractText | Unmethylated CpG-containing DNA plays a critical role in immunity via the augmentation of Th1 but suppression of Th2 T cell responses. We describe here that CpG motifs also redirect isotype production by murine B cells to "Th1-like" Ig isotypes (IgG2a, IgG2b, and IgG3) while suppressing Th2 isotypes (IgG1 and IgE). Using genetically mutant B cells, we find that the IgG2a, IgG2b and IgG3 isotypes are transcriptionally regulated via the promotion of class-switching, in a manner critically dependent upon TLR9 and MyD88. Thus, CpG DNA redirects Ig isotype production by regulating the specificity of class-switch recombination. |
