| First Author | Piggott DA | Year | 2005 |
| Journal | J Clin Invest | Volume | 115 |
| Issue | 2 | Pages | 459-67 |
| PubMed ID | 15650773 | Mgi Jnum | J:96199 |
| Mgi Id | MGI:3529665 | Doi | 10.1172/JCI22462 |
| Citation | Piggott DA, et al. (2005) MyD88-dependent induction of allergic Th2 responses to intranasal antigen. J Clin Invest 115(2):459-67 |
| abstractText | MyD88 is a common Toll-like receptor (TLR) adaptor molecule found to be essential for induction of adaptive Th1 immunity. Conversely, innate control of adaptive Th2 immunity has been shown to occur in a MyD88-independent manner. In this study, we show that MyD88 is an essential innate component in the induction of TLR4-dependent Th2 responses to intranasal antigen; thus we demonstrate what we believe to be a novel role for MyD88 in pulmonary Th2 immunity. Induction of the MyD88-independent type I IFN response to LPS is defective in the pulmonary environment. Moreover, in the absence of MyD88, LPS-induced upregulation of costimulatory molecule expression on pulmonary DCs is defective, in contrast to what has been observed with bone marrow-derived DCs (BMDCs). Reconstitution of Th2 responses occurs upon adoptive pulmonary transfer of activated BMDCs to MyD88-deficient recipients. Furthermore, the dependence of Th2 responses on MyD88 is governed by the initial route of antigen exposure; this demonstrates what we believe are novel site-specific innate mechanisms for control of adaptive Th2 immunity. |
