| First Author | Gavin AL | Year | 2006 |
| Journal | Science | Volume | 314 |
| Issue | 5807 | Pages | 1936-8 |
| PubMed ID | 17185603 | Mgi Jnum | J:116772 |
| Mgi Id | MGI:3695006 | Doi | 10.1126/science.1135299 |
| Citation | Gavin AL, et al. (2006) Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. Science 314(5807):1936-8 |
| abstractText | Innate immune signals mediated by Toll-like receptors (TLRs) have been thought to contribute considerably to the antibody-enhancing effects of vaccine adjuvants. However, we report here that mice deficient in the critical signaling components for TLR mount robust antibody responses to T cell-dependent antigen given in four typical adjuvants: alum, Freund's complete adjuvant, Freund's incomplete adjuvant, and monophosphoryl-lipid A/trehalose dicorynomycolate adjuvant. We conclude that TLR signaling does not account for the action of classical adjuvants and does not fully explain the action of a strong adjuvant containing a TLR ligand. This may have important implications in the use and development of vaccine adjuvants. |
