| First Author | Gil-Cruz C | Year | 2016 |
| Journal | Nat Immunol | Volume | 17 |
| Issue | 12 | Pages | 1388-1396 |
| PubMed ID | 27798617 | Mgi Jnum | J:259569 |
| Mgi Id | MGI:6141885 | Doi | 10.1038/ni.3566 |
| Citation | Gil-Cruz C, et al. (2016) Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs. Nat Immunol 17(12):1388-1396 |
| abstractText | Fibroblastic reticular cells (FRCs) of secondary lymphoid organs form distinct niches for interaction with hematopoietic cells. We found here that production of the cytokine IL-15 by FRCs was essential for the maintenance of group 1 innate lymphoid cells (ILCs) in Peyer''s patches and mesenteric lymph nodes. Moreover, FRC-specific ablation of the innate immunological sensing adaptor MyD88 unleashed IL-15 production by FRCs during infection with an enteropathogenic virus, which led to hyperactivation of group 1 ILCs and substantially altered the differentiation of helper T cells. Accelerated clearance of virus by group 1 ILCs precipitated severe intestinal inflammatory disease with commensal dysbiosis, loss of intestinal barrier function and diminished resistance to colonization. In sum, FRCs act as an ''on-demand'' immunological ''rheostat'' by restraining activation of group 1 ILCs and thereby preventing immunopathological damage in the intestine. |
