| First Author | Mallick-Wood CA | Year | 1998 |
| Journal | Science | Volume | 279 |
| Issue | 5357 | Pages | 1729-33 |
| PubMed ID | 9497293 | Mgi Jnum | J:46358 |
| Mgi Id | MGI:1197774 | Doi | 10.1126/science.279.5357.1729 |
| Citation | Mallick-Wood CA, et al. (1998) Conservation of T cell receptor conformation in epidermal gammadelta cells with disrupted primary Vgamma gene usage. Science 279(5357):1729-33 |
| abstractText | A feature that distinguishes gammadelta T cell subsets from most alphabeta T cells and B cells is the association of expression of single T cell receptor (TCR) gamma and delta variable (V) region gene segments with specific anatomic sites. Mice lacking the TCR Vgamma5 chain normally expressed by most dendritic epidermal T cells were shown to retain a conformational determinant (idiotype) ordinarily expressed exclusively by such Vgamma5+ cells. Conservation by shuffled gammadelta TCR chains of an idiotype associated with a specific anatomic site indicates that for TCRgammadelta, as for immunoglobulin, conformation is associated to a greater extent with the function or development of lymphocyte repertoires than is the use of particular gene segments. |
