| First Author | da Silva AA | Year | 2022 |
| Journal | Am J Physiol Regul Integr Comp Physiol | Volume | 322 |
| Issue | 5 | Pages | R421-R433 |
| PubMed ID | 35318854 | Mgi Jnum | J:322494 |
| Mgi Id | MGI:7257900 | Doi | 10.1152/ajpregu.00300.2021 |
| Citation | da Silva AA, et al. (2022) Parental obesity alters offspring blood pressure regulation and cardiovascular responses to stress: role of P2X7R and sex differences. Am J Physiol Regul Integr Comp Physiol |
| abstractText | We examined the impact of parental obesity on offspring blood pressure (BP) regulation and cardiovascular responses to stress. Offspring from normal (N) diet-fed C57BL/6J parents were fed either N (NN) or a high fat (H) diet (NH) from weaning until adulthood. Offspring from obese H diet-fed parents were also fed N (HN) or H diet (HH). Body weight, calorie intake and fat mass were measured at 22 weeks of age when cardiovascular phenotyping was performed. Male and female HH offspring were 15% heavier than NH and 70% heavier than NN offspring. Male HH and HN offspring had elevated BP (121+/-2 and 115+/-1 mmHg, by telemetry) compared to male NH and NN offspring (108+/-6 and 107+/-3 mmHg, respectively) and augmented BP responses to angiotensin II, losartan and hexamethonium. Male HH and HN offspring also showed increased BP responses to air-jet stress (37+/-2 and 38+/-2 mmHg) compared to only 24+/-3 and 25+/-3 mmHg in NH and NN offspring. Baseline heart rate (HR) and HR responses to air-jet stress were similar among groups. In females, BP and cardiovascular responses to stress were similar among all offspring. Male H diet-fed offspring from obese H diet-fed purinoreceptor 7 deficient (HH-P2X7R-KO) parents had normal BP that was similar to control NN-P2X7R-KO offspring from lean parents. These results indicate that parental obesity leads to increased BP and augmented BP responses to stress in their offspring in a sex-dependent manner and that the impact of parental obesity on male offspring BP regulation is markedly attenuated in P2X7R-KO mice. |
