| Primary Identifier | MGI:2384740 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Mt1-Esr1)1Vld |
| Strain of Origin | FVB/N | Is Recombinase | false |
| Is Wild Type | false |
| description | Six different transgenic founders were created and designated founders A-E. Transgene copy number varied from 1-46, and all founders expressed the transgene at the highest levels in the female reproductive tract. Low to moderate transgene expression was observed in some non-reproductive tissues. All founders exhibit age-related reproductive phenotypes including reduced fertility, extended gestation times, stillbirths, prolonged difficult labor (dystocia), and birth trauma. |
| molecularNote | The full-length mouse Esr1 cDNA fused to the mouse metallothionein 1 promoter was used for the transgene. Unexpectedly, no expression of the transgene was found in the liver. Expression of the transgene was verified by ribonuclease protection assay (RPA). |
