| First Author | Cholfin JA | Year | 2007 |
| Journal | Proc Natl Acad Sci U S A | Volume | 104 |
| Issue | 18 | Pages | 7652-7 |
| PubMed ID | 17442747 | Mgi Jnum | J:121300 |
| Mgi Id | MGI:3709777 | Doi | 10.1073/pnas.0702225104 |
| Citation | Cholfin JA, et al. (2007) Patterning of frontal cortex subdivisions by Fgf17. Proc Natl Acad Sci U S A 104(18):7652-7 |
| abstractText | The frontal cortex (FC) is the seat of higher cognition. The genetic mechanisms that control formation of the functionally distinct subdivisions of the FC are unknown. Using a set of gene expression markers that distinguish subdivisions of the newborn mouse FC, we show that loss of Fgf17 selectively reduces the size of the dorsal FC whereas ventral/orbital FC appears normal. These changes are complemented by a rostral shift of sensory cortical areas. Thus, Fgf17 functions similar to Fgf8 in patterning the overall neocortical map but has a more selective role in regulating the properties of the dorsal but not ventral FC. |
