| First Author | de Barreda EG | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 11 | Pages | 2265-70 |
| PubMed ID | 20338169 | Mgi Jnum | J:160378 |
| Mgi Id | MGI:4454362 | Doi | 10.1016/j.febslet.2010.03.032 |
| Citation | de Barreda EG, et al. (2010) Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repression. FEBS Lett 584(11):2265-70 |
| abstractText | Although tau is mainly located in the cell cytoplasm, mostly bound to tubulin, it may also be found in the nucleus of neurons. Hence, we tested whether tau might play a role in regulating the expression of certain genes by comparing gene expression in mice containing or lacking the tau protein. Our results identified a significant difference in the expression of the smarce1 gene, which codes for the BAF-57 protein, a protein involved in the repression of neuron specific genes. These data suggest a role for tau in neuron maturation. |
