| First Author | Jiao L | Year | 2020 |
| Journal | FASEB J | Volume | 34 |
| Issue | 9 | Pages | 12239-12254 |
| PubMed ID | 33000527 | Mgi Jnum | J:329509 |
| Mgi Id | MGI:6714461 | Doi | 10.1096/fj.202000017RR |
| Citation | Jiao L, et al. (2020) Tau knockout exacerbates degeneration of parvalbumin-positive neurons in substantia nigra pars reticulata in Parkinson's disease-related alpha-synuclein A53T mice. FASEB J 34(9):12239-12254 |
| abstractText | alpha-Synuclein (alpha-syn)-induced neurotoxicity has been generally accepted as a key step in the pathogenesis of Parkinson's disease (PD). Microtubule-associated protein tau, which is considered second only to alpha-syn, has been repeatedly linked with PD in association studies. However, the underlying interaction between these two PD-related proteins in vivo remains unclear. To investigate how the expression of tau affects alpha-syn-induced neurodegeneration in vivo, we generated triple transgenic mice that overexpressed alpha-syn A53T mutation in the midbrain dopaminergic neurons (mDANs) with different expression levels of tau. Here, we found that tau had no significant effect on the A53T alpha-syn-mediated mDANs degeneration. However, tau knockout could modestly promote the formation of alpha-syn aggregates, accelerate the severe and progressive degeneration of parvalbumin-positive (PV(+)) neurons in substantia nigra pars reticulata (SNR), accompanied with anxiety-like behavior in aged PD-related alpha-syn A53T mice. The mechanisms may be associated with A53T alpha-syn-mediated specifically successive impairment of N-methyl-d-aspartate receptor subunit 2B (NR2B), postsynaptic density-95 (PSD-95) and microtubule-associated protein 1A (MAP1A) in PV(+) neurons. Our study indicates that MAP1A may play a beneficial role in preserving the survival of PV(+) neurons, and that inhibition of the impairment of NR2B/PSD-95/MAP1A pathway, may be a novel and preferential option to ameliorate alpha-syn-induced neurodegeneration. |
