| First Author | Uchida Y | Year | 2011 |
| Journal | FEBS Lett | Volume | 585 |
| Issue | 4 | Pages | 651-6 |
| PubMed ID | 21256848 | Mgi Jnum | J:169111 |
| Mgi Id | MGI:4939864 | Doi | 10.1016/j.febslet.2011.01.025 |
| Citation | Uchida Y, et al. (2011) Up-regulation of calsyntenin-3 by beta-amyloid increases vulnerability of cortical neurons. FEBS Lett 585(4):651-6 |
| abstractText | beta-Amyloid (Abeta) may play an important role in the pathogenesis of Alzheimer's disease. However, a causal relationship between Abeta oligomers and layer-specific neurodegeneration has not been clarified. Here we show up-regulation of calsyntenin (Cst)-3 in cultured neurons treated with Abeta oligomers and in Tg2576 mice. Cst-3 is distributed in large neurons in layers 2-3 and 5 of the cerebral cortex, and accumulated in dystrophic neurites surrounding Abeta-plaques. Overexpression of Cst-3 accelerates neuronal death. These results indicate that up-regulation of Cst-3 in cortical neurons in layers 2-3 and 5 by Abeta oligomers may lead to increase in vulnerability of neurons. |
