| First Author | Yang F | Year | 2000 |
| Journal | Brain Res | Volume | 853 |
| Issue | 2 | Pages | 381-3 |
| PubMed ID | 10640638 | Mgi Jnum | J:174836 |
| Mgi Id | MGI:5141221 | Doi | 10.1016/s0006-8993(99)02207-6 |
| Citation | Yang F, et al. (2000) Plaque-associated alpha-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein. Brain Res 853(2):381-3 |
| abstractText | Patients with the Lewy body variant (LBV) of Alzheimer's disease (AD) have ubiquitinated intraneuronal and neuritic accumulations of alpha-synuclein and show less neuron loss and tau pathology than other AD patients. Aged Tg2576 transgenic mice overexpressing human betaAPP695. KM670/671NL have limited neuron loss and tau pathology, but frequent ubiquitin- and alpha-synuclein-positive, tau-negative neurites resembling those seen in the LBV of AD. |
