| First Author | Pappolla M | Year | 2014 |
| Journal | Neurobiol Dis | Volume | 71 |
| Pages | 215-9 | PubMed ID | 25102344 |
| Mgi Jnum | J:218329 | Mgi Id | MGI:5617306 |
| Doi | 10.1016/j.nbd.2014.07.012 | Citation | Pappolla M, et al. (2014) Evidence for lymphatic Abeta clearance in Alzheimer's transgenic mice. Neurobiol Dis 71:215-9 |
| abstractText | Evidence has shown that lymphatic drainage contributes to removal of debris from the brain but its role in the accumulation of amyloid beta peptides (Abeta) has not been demonstrated. We examined the levels of various forms of Abeta in the brain, plasma and lymph nodes in a transgenic model of Alzheimer's disease (AD) at different ages. Herein, we report on the novel finding that Abeta is present in the cervical and axillary lymph nodes of AD transgenic mice and that Abeta levels in lymph nodes increase over time, mirroring the increase of Abeta levels observed in the brain. Abeta levels in lymph nodes were significantly higher than in plasma. At age 15.5months, there was a significant increase of monomeric soluble Abeta40 (p=0.003) and Abeta42 (p=0.05) in the lymph nodes over the baseline values measured at 6months of age. In contrast, plasma levels of Abeta40 showed no significant changes (p=0.68) and plasma levels Abeta42 significantly dropped (p=0.02) at the same age. Abeta concentration was low to undetectable in splenic lymphoid tissue and several other control tissues including heart, lung, liver, kidneys and intestine of the same animals, strongly suggesting that Abeta peptides in lymph nodes are derived from the brain. |
