| First Author | Moore KM | Year | 2016 |
| Journal | Neurobiol Dis | Volume | 85 |
| Pages | 218-224 | PubMed ID | 26563933 |
| Mgi Jnum | J:228742 | Mgi Id | MGI:5708781 |
| Doi | 10.1016/j.nbd.2015.11.004 | Citation | Moore KM, et al. (2016) A spectrum of exercise training reduces soluble Abeta in a dose-dependent manner in a mouse model of Alzheimer's disease. Neurobiol Dis 85:218-24 |
| abstractText | Physical activity has long been hypothesized to influence the risk and pathology of Alzheimer's disease. However, the amount of physical activity necessary for these benefits is unclear. We examined the effects of three months of low and high intensity exercise training on soluble Abeta40 and Abeta42 levels in extracellular enriched fractions from the cortex and hippocampus of young Tg2576 mice. Low (LOW) and high (HI) intensity exercise training animals ran at speeds of 15m/min on a level treadmill and 32m/min at a 10% grade, respectively for 60min per day, five days per week, from three to six months of age. Sedentary mice (SED) were placed on a level, non-moving, treadmill for the same duration. Soleus muscle citrate synthase activity increased by 39% in the LOW group relative to SED, and by 71% in the HI group relative to LOW, indicating an exercise training effect in these mice. Soluble Abeta40 concentrations decreased significantly in an exercise training dose-dependent manner in the cortex. In the hippocampus, concentrations were decreased significantly in the HI group relative to LOW and SED. Soluble Abeta42 levels also decreased significantly in an exercise training dose-dependent manner in both the cortex and hippocampus. Five proteins involved in Abeta clearance (neprilysin, IDE, MMP9, LRP1 and HSP70) were elevated by exercise training with its intensity playing a role in each case. Our data demonstrate that exercise training reduces extracellular soluble Abeta in the brains of Tg2576 mice in a dose-dependent manner through an up-regulation of Abeta clearance. |
