| First Author | Bero AW | Year | 2011 |
| Journal | Nat Neurosci | Volume | 14 |
| Issue | 6 | Pages | 750-6 |
| PubMed ID | 21532579 | Mgi Jnum | J:173925 |
| Mgi Id | MGI:5050564 | Doi | 10.1038/nn.2801 |
| Citation | Bero AW, et al. (2011) Neuronal activity regulates the regional vulnerability to amyloid-beta deposition. Nat Neurosci 14(6):750-6 |
| abstractText | Amyloid-beta (Abeta) plaque deposition in specific brain regions is a pathological hallmark of Alzheimer's disease. However, the mechanism underlying the regional vulnerability to Abeta deposition in Alzheimer's disease is unknown. Herein, we provide evidence that endogenous neuronal activity regulates the regional concentration of interstitial fluid (ISF) Abeta, which drives local Abeta aggregation. Using in vivo microdialysis, we show that ISF Abeta concentrations in several brain regions of APP transgenic mice before plaque deposition were commensurate with the degree of subsequent plaque deposition and with the concentration of lactate, a marker of neuronal activity. Furthermore, unilateral vibrissal stimulation increased ISF Abeta, and unilateral vibrissal deprivation decreased ISF Abeta and lactate, in contralateral barrel cortex. Long-term unilateral vibrissal deprivation decreased amyloid plaque formation and growth. Our results suggest a mechanism to account for the vulnerability of specific brain regions to Abeta deposition in Alzheimer's disease. |
