| First Author | Barnes P | Year | 2005 |
| Journal | Behav Brain Res | Volume | 157 |
| Issue | 1 | Pages | 107-17 |
| PubMed ID | 15617777 | Mgi Jnum | J:95243 |
| Mgi Id | MGI:3525740 | Doi | 10.1016/j.bbr.2004.06.014 |
| Citation | Barnes P, et al. (2005) Impaired Pavlovian cued fear conditioning in Tg2576 mice expressing a human mutant amyloid precursor protein gene. Behav Brain Res 157(1):107-17 |
| abstractText | The processing of emotional and/or fear-related events is abnormal in patients with Alzheimer's disease. AD is accompanied by a number of neuropathological features, one of which is the deposition of amyloid plaques. The main aim of the present study was to examine the effects of a human amyloid precursor protein mutation on both the acquisition and expression of fear conditioning in Tg2576 mice. Sixteen-month-old, but not 4-month-old, transgenic mice showed aberrations in post-shock freezing during training. In a retention test carried out 24h after training, Tg2576 mice showed comparable levels of conditioned fear elicited by contextual cues. However, freezing elicited by a tone conditioned stimulus was impaired in 16-month-old but not 4-month-old Tg2576 mice. The results are discussed with reference to the role of cue competition (overshadowing) in revealing fear conditioning deficits in Tg2576 mice. |
