| Primary Identifier | MGI:2385652 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Rbp3-SV40)IT-2Jjw |
| Strain of Origin | (BALB/cAnNHsd x C57BL/6NHsd)F2 | Is Recombinase | false |
| Is Wild Type | false |
| description | Transgenic animals develop retinal and pineal tumors by 10-12 weeks of age with 100% penetrance. Transgenic animals carrying the greatest transgene copy number (15-50) also displayed a 25%-30% decrease in body weight compared to non-transgenic animals. |
| molecularNote | 2.7 kb of the SV40 T antigen gene fused to 1.9 kb of mouse RBP3 promoter sequences was used as the transgene. Promoter sequences from -1783 to +101 were used to drive expression of the transgene in photoreceptor cells. Northern blot analysis confirmed transgene expression in the retina and pineal of transgenic animals. |
