| First Author | Gruber T | Year | 2005 |
| Journal | Immunol Lett | Volume | 96 |
| Issue | 2 | Pages | 291-3 |
| PubMed ID | 15585335 | Mgi Jnum | J:105091 |
| Mgi Id | MGI:3613416 | Doi | 10.1016/j.imlet.2004.08.011 |
| Citation | Gruber T, et al. (2005) PKCdelta is involved in signal attenuation in CD3+ T cells. Immunol Lett 96(2):291-3 |
| abstractText | PKCdelta has been implicated in the signalling events after engagement of the antigen specific receptor on B cells and the Fc-varepsilon receptor on mast cells. Employing our recently established PKCdelta null mice , we here investigate the physiological function of PKCdelta in CD3+ T cells. As result, administration of anti-CD3 antibodies in vivo induced markedly increased blood plasma IL-2 levels (but not IL-4, IFN-gamma, TNF-alpha and IL-6 levels) in the PKCdelta null mice, when compared to wild-type sibling controls. Additionally, in vitro T cell proliferative responses to allogenic MHC are significantly enhanced in PKCdelta-deficient CD3+ T cells. These findings suggest that PKCdelta serves a so far unrecognized role in TCR-induced negative regulation of IL-2 cytokine production and T cell proliferation. |
