| First Author | Carracedo S | Year | 2013 |
| Journal | BMC Dev Biol | Volume | 13 |
| Pages | 2 | PubMed ID | 23305608 |
| Mgi Jnum | J:193248 | Mgi Id | MGI:5468038 |
| Doi | 10.1186/1471-213X-13-2 | Citation | Carracedo S, et al. (2013) Expression pattern of protein kinase Cdelta during mouse embryogenesis. BMC Dev Biol 13:2 |
| abstractText | BACKGROUND: The members of the protein kinase C (PKC) family consist of serine/threonine kinases classified according to their regulatory domain. Those that belong to the novel PKC subfamily, such as PKCdelta, are dependent on diacylglycerol but not Calcium when considering their catalytic activity. Although several studies have shown the importance of PKCdelta in different cellular events in health and disease, the overall in vivo distribution of this PKC isoform during development is still lacking. Through Lac Z and antibody staining procedures, we show here the in vivo expression of PKCdelta during mouse embryogenesis. RESULTS: Ganglia were the domains with most prominent expression of PKCdelta in most of the stages analysed, although PKCdelta could also be detected in heart and somites at earlier stages, and cartilage primordium and skin among other sites in older embryos. CONCLUSIONS: The strong expression of PKCdelta in ganglia during murine development shown in this study suggests a significant role of this isoform as well as redundancy with other PKCs within the nervous system, since PKCdelta deficient mice develop normally. |
