| First Author | Atkinson SJ | Year | 2018 |
| Journal | EMBO Rep | Volume | 19 |
| Issue | 7 | PubMed ID | 29794156 |
| Mgi Jnum | J:264821 | Mgi Id | MGI:6188484 |
| Doi | 10.15252/embr.201744578 | Citation | Atkinson SJ, et al. (2018) The beta3-integrin endothelial adhesome regulates microtubule-dependent cell migration. EMBO Rep 19(7) |
| abstractText | Integrin beta3 is seen as a key anti-angiogenic target for cancer treatment due to its expression on neovasculature, but the role it plays in the process is complex; whether it is pro- or anti-angiogenic depends on the context in which it is expressed. To understand precisely beta3's role in regulating integrin adhesion complexes in endothelial cells, we characterised, by mass spectrometry, the beta3-dependent adhesome. We show that depletion of beta3-integrin in this cell type leads to changes in microtubule behaviour that control cell migration. beta3-integrin regulates microtubule stability in endothelial cells through Rcc2/Anxa2-driven control of active Rac1 localisation. Our findings reveal that angiogenic processes, both in vitro and in vivo, are more sensitive to microtubule targeting agents when beta3-integrin levels are reduced. |
