| First Author | Zee T | Year | 2017 |
| Journal | Nat Med | Volume | 23 |
| Issue | 3 | Pages | 288-290 |
| PubMed ID | 28165480 | Mgi Jnum | J:254803 |
| Mgi Id | MGI:6103813 | Doi | 10.1038/nm.4280 |
| Citation | Zee T, et al. (2017) alpha-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria. Nat Med 23(3):288-290 |
| abstractText | Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutritional supplement alpha-lipoic acid inhibits cystine stone formation in the Slc3a1(-/-) mouse model of cystinuria by increasing the solubility of urinary cystine. These findings identify a novel therapeutic strategy for the clinical treatment of cystinuria. |
