| First Author | van Spriel AB | Year | 2004 |
| Journal | J Immunol | Volume | 172 |
| Issue | 5 | Pages | 2953-61 |
| PubMed ID | 14978098 | Mgi Jnum | J:88241 |
| Mgi Id | MGI:3029813 | Doi | 10.4049/jimmunol.172.5.2953 |
| Citation | van Spriel AB, et al. (2004) A regulatory role for CD37 in T cell proliferation. J Immunol 172(5):2953-61 |
| abstractText | CD37 is a leukocyte-specific protein belonging to the tetraspanin superfamily. Previously thought to be predominantly a B cell molecule, CD37 is shown in this study to regulate T cell proliferation. CD37-deficient (CD37(-/-)) T cells were notably hyperproliferative in MLR, in response to Con A, or CD3-TCR engagement particularly in the absence of CD28 costimulation. Hyperproliferation was not due to differences in memory to naive T cell ratios in CD37(-/-) mice, apoptosis, or TCR down-modulation. Division cycle analyses revealed CD37(-/-) T cells to enter first division earlier than wild-type T cells. Importantly, proliferation of CD37(-/-) T cells was preceded by enhanced early IL-2 production. We hypothesized CD37 to be involved in TCR signaling and this was supported by the observation that CD4/CD8-associated p56(Lck) kinase activity was increased in CD37(-/-) T cells. Remarkably, CD37 cross-linking on human T cells transduced signals that led to complete inhibition of CD3-induced proliferation. In the presence of CD28 costimulation, CD37 engagement still significantly reduced proliferation. Taken together, these results demonstrate a regulatory role for CD37 in T cell proliferation by influencing early events of TCR signaling. |
