| First Author | Loughran SJ | Year | 2008 |
| Journal | Nat Immunol | Volume | 9 |
| Issue | 7 | Pages | 810-9 |
| PubMed ID | 18500345 | Mgi Jnum | J:137835 |
| Mgi Id | MGI:3803042 | Doi | 10.1038/ni.1617 |
| Citation | Loughran SJ, et al. (2008) The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat Immunol 9(7):810-9 |
| abstractText | Ets-related gene (ERG), which encodes a member of the Ets family of transcription factors, is a potent oncogene. Chromosomal rearrangements involving ERG are found in acute myeloid leukemia, acute lymphoblastic leukemia, Ewing's sarcoma and more than half of all prostate cancers; however, the normal physiological function of Erg is unknown. We did a sensitized genetic screen of the mouse for regulators of hematopoietic stem cell function and report here a germline mutation of Erg. We show that Erg is required for definitive hematopoiesis, adult hematopoietic stem cell function and the maintenance of normal peripheral blood platelet numbers. |
