| First Author | Deppong C | Year | 2008 |
| Journal | J Immunol | Volume | 181 |
| Issue | 5 | Pages | 2973-9 |
| PubMed ID | 18713967 | Mgi Jnum | J:138965 |
| Mgi Id | MGI:3806915 | Doi | 10.4049/jimmunol.181.5.2973 |
| Citation | Deppong C, et al. (2008) B and T lymphocyte attenuator regulates T cell survival in the lung. J Immunol 181(5):2973-9 |
| abstractText | The initiation, intensity, and duration of T cell-directed inflammatory responses are dependent upon the coordination of both activating and inhibitory signals mediated by specific receptors on the T lymphocyte. The recently described receptor, B and T lymphocyte attenuator (BTLA), has been demonstrated to have an important role in limiting the duration of inflammation in a murine model of allergic asthma. In this study, we have examined the role of BTLA on the proliferation, recruitment, and survival of T cells in response to inhaled allergen. We find that there is decreased cell death in T cells from BTLA-deficient mice, whereas proliferation and recruitment to the lungs are unchanged. Thus, the regulation of cell death through BTLA signaling is a key determinant of the inflammatory response in the lung. |
