| First Author | Wang L | Year | 2007 |
| Journal | Eur J Immunol | Volume | 37 |
| Issue | 10 | Pages | 2983-90 |
| PubMed ID | 17899549 | Mgi Jnum | J:125339 |
| Mgi Id | MGI:3758352 | Doi | 10.1002/eji.200737583 |
| Citation | Wang L, et al. (2007) Programmed cell death 1 (PD-1) and its ligand PD-L1 are required for allograft tolerance. Eur J Immunol 37(10):2983-90 |
| abstractText | Programmed cell death-1 (PD-1, CD279) and its widely expressed, inducible ligand, PD-L1 (CD274), together dampen T cell activation, but whether they are essential for allograft tolerance is unknown. We show, using gene-deficient mice and blocking mAbs in wild-type mice, that costimulation blockade is ineffectual in PD-1(-/-) or PD-L1(-/-) allograft recipients, or in wild-type allograft recipients treated with anti-PD-1 or anti-PD-L1 mAb. Alloreactive PD-1(-/-) CD4 and CD8 T cells had enhanced proliferation and cytokine production compared to wild-type controls, and anergy could not be induced in PD-1-deficient CD4 T cells. We conclude that without inhibitory signals from PD-1 ligation, alloantigen-induced T cell proliferation and expansion cannot be regulated by costimulation blockade, and peripheral tolerance induction cannot occur. |
