Primary Identifier | MGI:2386196 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Lyn |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exon 4, which encodes the amino terminal portion of the SH3 domain, was disrupted by the insertion of neomycin selection cassette. The absence of both isoforms was verified by Western blot analysis of spleen and cerebellum tissue obtained from homozygous mutant mice. |