| First Author | Peperzak V | Year | 2013 |
| Journal | J Immunol | Volume | 191 |
| Issue | 6 | Pages | 3025-36 |
| PubMed ID | 23940275 | Mgi Jnum | J:205765 |
| Mgi Id | MGI:5546432 | Doi | 10.4049/jimmunol.1202222 |
| Citation | Peperzak V, et al. (2013) CD8+ T cells produce the chemokine CXCL10 in response to CD27/CD70 costimulation to promote generation of the CD8+ effector T cell pool. J Immunol 191(6):3025-36 |
| abstractText | Various cell types can produce the chemokine CXCL10 in response to IFN-gamma stimulation. CXCL10 is generally viewed as a proinflammatory chemokine that promotes recruitment of CD8/ and Th1-type CD4/ effector T cells to infected or inflamed nonlymphoid tissues. We show that CXCL10 plays a role during CD8/ T cell priming in the mouse. Genome-wide expression profiling revealed the Cxcl10 gene as a target of CD27/CD70 costimulation in newly activated CD8/ T cells. CD27/CD70 costimulation is known to promote activated T cell survival, but CXCL10 did not affect survival or proliferation of primed CD8/ T cells in vitro. Accordingly, CXCL10 could not fully rescue CD27 deficiency in mice infected with influenza virus. Rather, CXCL10 acted as chemoattractant for other activated CD8(+) T cells. It signaled downstream of CD27 in a paracrine fashion to promote generation of the CD8/ effector T cell pool in the Ag-draining lymph nodes. Consistently, CD8/ T cells required expression of the CXCL10 receptor CXCR3 for their clonal expansion in a CD27/CD70-dependent peptide-immunization model. Our findings indicate that CXCL10, produced by primed CD8/ T cells in response to CD27/CD70 costimulation, signals to other primed CD8(+) T cells in the lymph node microenvironment to facilitate their participation in the CD8/ effector T cell pool. |
