| Primary Identifier | MGI:2386397 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Renbp |
| Transmission | Germline | Strain of Origin | 129/SvEmcTer |
| Is Recombinase | false | Is Wild Type | false |
| description | ES cell line = ICp4. |
| molecularNote | The gene was disrupted by replacement of a 1 kb region including part of exon 5 and exon 6 with a neomycin resistance cassette via homologous recombination. The targeted mutation results in deletion of sequences encoding a leucine zipper motif, which is required for interaction with renin. Homozygous mutant animals did not express gene transcripts as determined by Northern blot analysis of kidney RNA. |
