| First Author | Federico A | Year | 2014 |
| Journal | Biol Open | Volume | 3 |
| Issue | 5 | Pages | 372-8 |
| PubMed ID | 24728959 | Mgi Jnum | J:211181 |
| Mgi Id | MGI:5574234 | Doi | 10.1242/bio.20146759 |
| Citation | Federico A, et al. (2014) Hmga1/Hmga2 double knock-out mice display a "superpygmy" phenotype. Biol Open 3(5):372-8 |
| abstractText | The HMGA1 and HMGA2 genes code for proteins belonging to the High Mobility Group A family. Several genes are negatively or positively regulated by both these proteins, but a number of genes are specifically regulated by only one of them. Indeed, knock-out of the Hmga1 and Hmga2 genes leads to different phenotypes: cardiac hypertrophy and type 2 diabetes in the former case, and a large reduction in body size and amount of fat tissue in the latter case. Therefore, to better elucidate the functions of the Hmga genes, we crossed Hmga1-null mice with mice null for Hmga2. The Hmga1(-/-)/Hmga2(-/-) mice showed reduced vitality and a very small size (75% smaller than the wild-type mice); they were even smaller than pygmy Hmga2-null mice. The drastic reduction in E2F1 activity, and consequently in the expression of the E2F-dependent genes involved in cell cycle regulation, likely accounts for some phenotypic features of the Hmga1(-/-)/Hmga2(-/-) mice. |
