| First Author | Mahlakõiv T | Year | 2019 |
| Journal | Sci Immunol | Volume | 4 |
| Issue | 35 | PubMed ID | 31053655 |
| Mgi Jnum | J:290597 | Mgi Id | MGI:6443832 |
| Doi | 10.1126/sciimmunol.aax0416 | Citation | Mahlakoiv T, et al. (2019) Stromal cells maintain immune cell homeostasis in adipose tissue via production of interleukin-33. Sci Immunol 4(35) |
| abstractText | Obesity is driven by chronic low-grade inflammation resulting from dysregulated immune cell accumulation and function in white adipose tissue (WAT). Interleukin-33 (IL-33) is a key cytokine that controls innate and adaptive immune cell activity and immune homeostasis in WAT, although the sources of IL-33 have remained controversial. Here, we show that WAT-resident mesenchyme-derived stromal cells are the dominant producers of IL-33. Adipose stem and progenitor cells (ASPCs) produced IL-33 in all WAT depots, whereas mesothelial cells served as an additional source of IL-33 in visceral WAT. ASPC-derived IL-33 promoted a regulatory circuit that maintained an immune tone in WAT via the induction of group 2 innate lymphoid cell-derived type 2 cytokines and maintenance of eosinophils, whereas mesothelial IL-33 also acted as an alarmin by inducing peritoneal immune response upon infection. Together, these data reveal a previously unrecognized regulatory network between tissue-resident progenitor cells and innate lymphoid cells that maintains immune homeostasis in adipose tissue. |
