| First Author | Guo L | Year | 2015 |
| Journal | Nat Immunol | Volume | 16 |
| Issue | 10 | Pages | 1051-9 |
| PubMed ID | 26322482 | Mgi Jnum | J:233650 |
| Mgi Id | MGI:5787750 | Doi | 10.1038/ni.3244 |
| Citation | Guo L, et al. (2015) Innate immunological function of TH2 cells in vivo. Nat Immunol 16(10):1051-9 |
| abstractText | Type 2 helper T cells (TH2 cells) produce interleukin 13 (IL-13) when stimulated by papain or house dust mite extract (HDM) and induce eosinophilic inflammation. This innate response is dependent on IL-33 but not T cell antigen receptors (TCRs). While type 2 innate lymphoid cells (ILC2 cells) are the dominant innate producers of IL-13 in naive mice, we found here that helminth-infected mice had more TH2 cells compared to uninfected mice, and thes e cells became major mediators of innate type 2 responses. TH2 cells made important contributions to HDM-induced antigen-nonspecific eosinophilic inflammation and protected mice recovering from infection with Ascaris suum against subsequent infection with the phylogenetically distant nematode Nippostrongylus brasiliensis. Our findings reveal a previously unappreciated role for effector TH2 cells during TCR-independent innate-like immune responses. |
